Description
31 is a mitochondria-targeting tetrapeptide studied in controlled laboratory environments under the international nonproprietary name Elamipretide. Research interest in this compound centers on its interaction with cardiolipin — a phospholipid found almost exclusively in the inner mitochondrial membrane — and the role that interaction plays in membrane integrity, electron transport chain function, and mitochondrial bioenergetics research models.
Key Characteristics
- Aromatic-cationic tetrapeptide with an alternating aromatic and cationic amino acid sequence that facilitates membrane association
- Studied for selective localization to the inner mitochondrial membrane through cardiolipin binding in cell-based models
- Research interests include the observed effects on electron transport chain efficiency and ATP synthesis in mitochondrial function assays
- Investigated in models examining oxidative stress, mitochondrial membrane potential, and reactive oxygen species (ROS) signaling
- Water-soluble structure supports stability and handling across a range of controlled laboratory conditions
- Known in peer-reviewed literature as Elamipretide; also referenced by the internal designation 31
Handling and Storage
Consistent storage conditions are important for preserving compound integrity across the research period. 31 should be kept away from heat, moisture, and direct light. Its water-soluble structure supports reasonable stability under controlled conditions, but standard peptide handling practices apply from receipt through the conclusion of analytical procedures.
FAQs
What is 31?
31 is the internal designation for Elamipretide, an aromatic-cationic tetrapeptide studied for its cardiolipin binding activity and downstream effects on mitochondrial membrane integrity, electron transport chain efficiency, and oxidative stress signaling in cell-based research models.
What makes Elamipretide distinct from other mitochondria-targeting compounds?
Its alternating aromatic-cationic sequence allows it to associate with the inner mitochondrial membrane through cardiolipin binding without permanently accumulating there — a characteristic that distinguishes it from cationic compounds that rely on membrane potential for localization. This makes it a useful tool in research models where membrane potential-independent targeting is a study requirement.
What research models is 31 typically used in?
31 is most commonly selected for in vitro and cell-based models examining mitochondrial membrane integrity, electron transport chain function, ATP production efficiency, and oxidative stress pathway dynamics — particularly in contexts where cardiolipin interaction is the primary variable under investigation.
