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a vial of pinealon 10mg
an info card for PINEALON

Pinealon

Price range: $29.00 through $49.00

  • Contents: Pinealon (Glu-Asp-Arg; EDR tripeptide)
  • Form: Lyophilized powder
  • Purity: >99%
Quantity Discount Price
1 - 3 - -
4 - 7 10% -
8 + 18% -
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Description

Pinealon is a synthetic tripeptide bioregulator with the sequence Glu-Asp-Arg (EDR), developed by Professor Vladimir Khavinson at the St. Petersburg Institute of Bioregulation and Gerontology. Despite its name suggesting pineal gland origin, Pinealon originates from brain cortex extract research. The same Cortexin-based work that produced Cortagen. The two compounds differ by a single amino acid at the C-terminus: Cortagen carries proline (AEDP), Pinealon carries arginine (EDR as a tripeptide). Pinealon enters neuronal cell nuclei and modulates gene expression through direct peptide-DNA interaction. Its documented specialty research targets include antioxidant enzyme expression, MAPK/ERK signaling timing, and cell cycle regulatory proteins in CNS cell models.

Chemical Information

  • Chemical Name: Pinealon (Khavinson pineal gland/CNS-derived tripeptide bioregulator)
  • Also Known As: Pinealon peptide complex
  • Compound Class: Short-chain synthetic tripeptide; tissue-specific epigenetic bioregulator (Khavinson series)
  • Sequence: Glu-Asp-Arg, though not confirmed
  • Molecular Formula: Not established in public literature
  • Molecular Weight: Not established in public literature (consistent with the broader Khavinson class of low molecular weight peptides, <10,000 Da)
  • CAS Number: Not established in public literature

Applications

  • CNS and pineal-adjacent tissue gene regulation research. Pinealon is modeled on pineal gland and central nervous system tissue and is proposed to act via direct peptide-DNA interaction within neuronal and glial cell nuclei. It shares this mechanism with as Cortagen (cerebral cortex) and Cardiogen (cardiomyocytes)
  • Comparative neuroprotection and hypoxic stress research. Published work on structurally related cortex- and pineal-targeted Khavinson peptides has examined caspase-3 apoptotic pathway activity and cognitive performance in aged versus young animal models under hypoxic stress. Pinealon is studied within this comparative framework alongside Cortagen and Cortexin
  • Cross-tissue bioregulator specificity research. Pinealon is proposed to share its intranuclear DNA-interaction mechanism with other short-chain Khavinson peptides. As a result, researchers use it alongside tissue-matched and mismatched bioregulators to test whether reported neuroprotective effects are tissue-restricted or tissue-general

Storage and Handling

Store lyophilized powder under refrigeration (2-8C), protected from heat, light, and moisture. As a short-chain peptide, Pinealon is susceptible to proteolytic degradation once reconstituted. Reconstitute immediately before use, keep reconstituted solution refrigerated, and avoid repeated freeze-thaw cycles.

Compliance Notice

Pinealon is for laboratory research use only. It is not for human or veterinary use and carries no therapeutic, diagnostic, or clinical indication. FDA has not evaluated this product. By purchasing this product, the buyer confirms that they will follow appropriate institutional safety procedures and use it exclusively for controlled research.

Frequently Asked Questions

What is Pinealon?

Pinealon (EDR) is a synthetic tripeptide bioregulator from the Khavinson series, derived from brain cortex extract research despite its pineal-referencing name. It targets neuronal cell nuclei through direct peptide-DNA interaction and modulates antioxidant enzyme gene expression (SOD2, GPx1), MAPK/ERK signaling timing, and cell cycle regulatory proteins (PCNA, p21) in CNS preclinical models. All evidence is preclinical.

How does Pinealon differ from Cortagen within the Khavinson CNS series?

Both originate from brain cortex research and operate through the same intranuclear DNA-binding mechanism. The structural difference is a single amino acid. Cortagen ends in proline (AEDP tetrapeptide), Pinealon ends in arginine (EDR tripeptide). This difference is associated with distinct gene expression profiles. Cortagen's research focuses on cortical neuron gene regulation and BDNF expression in hippocampal tissue, while Pinealon's documented targets center on antioxidant enzyme upregulation and MAPK/ERK timing modulation.

Why is MAPK/ERK timing modulation significant in Pinealon research?

The finding is not simply that Pinealon increases or decreases ERK1/2 activity. It shifts the timing of ERK activation under oxidative stress from approximately 2.5 minutes to 20 minutes. Timing of MAPK cascade activation determines downstream gene expression outcomes. Earlier activation drives different cellular responses than delayed activation. This temporal shift is mechanistically specific to Pinealon. It is relevant in research designs examining how the timing of stress-response signaling, rather than its magnitude, affects neuronal outcome in oxidative challenge models.

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