Description
Selank is a synthetic tuftsin analog studied in controlled laboratory environments for its interaction with GABAergic signaling pathways and neuroimmune communication models.
Chemical Information
- Chemical Name: Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro; tuftsin heptapeptide analog)
- Also Known As: TP-7; Selanc
- Compound Class: Synthetic tuftsin-derived heptapeptide; multi-target CNS neuromodulator
- Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
- Molecular Formula: C33H57N11O9
- Molecular Weight: 751.9 g/mol
- CAS Number: 129954-34-3
- Origin: Developed at the Institute of Molecular Genetics, Russian Academy of Sciences, by extending the tuftsin tetrapeptide (Thr-Lys-Pro-Arg) with a C-terminal Pro-Gly-Pro sequence for enhanced metabolic stability
Applications
- GABA-A receptor positive allosteric modulation studies. Selank provides a mechanistic profile distinct from benzodiazepines; it modulates GABAergic gene expression in ways that benzodiazepines do not replicate, including blocking the modulatory activity of diazepam and olanzapine in receptor expression studies, making it a pharmacological tool for dissecting receptor subunit dynamics
- Enkephalin metabolism research. Selank is studied as a pharmacological tool for examining the consequences of extending enkephalin synaptic lifetime without direct opioid receptor agonism; experiments pair Selank with naloxone controls to confirm enkephalin-mediated effects
- Comparative gene expression studies. The 84-gene neurotransmission panel used by Volkova et al. has become a reference design for examining Selank’s broad genomic footprint. The same panel distinguishes Selank-specific gene regulation patterns from those of direct GABA agonists
- Neuroimmune intersection research. Selank retains tuftsin’s immunomodulatory properties, including documented modulation of 34 of 84 inflammation-related genes in mouse spleen (Uchakina et al. 2008), interleukin-6 effects, and selective interferon-alpha induction without affecting IL-4, IL-10, or TNF-alpha. This dual CNS/immune profile supports use in models examining neuroimmune signaling
- BDNF expression research in hippocampal models under stress conditions. Selank upregulates hippocampal BDNF mRNA in stressed rodent models where BDNF is otherwise suppressed; this is mechanistically adjacent to but distinct from Semax’s BDNF upregulation route, which operates through melanocortin receptor interaction rather than enkephalinergic stabilization
Storage and Handling
Store lyophilized powder at -20C for long-term stability, or at 2-8C for short-term use. Protect from heat, moisture, and direct light. The Pro-Gly-Pro C-terminal extension confers resistance to carboxypeptidase degradation, improving stability relative to the parent tuftsin sequence, though storage conditions remain important for long-term integrity. Reconstituted solutions should be stored at 2-8C and used promptly. Avoid repeated freeze-thaw cycles.
Compliance Notice
Selank is for laboratory research use only. They are not for human or veterinary use and carry no therapeutic, diagnostic, or clinical indication. FDA has not evaluated this product. By purchasing this product, the buyer confirms that they will follow appropriate institutional safety procedures and use it exclusively for controlled research.
