Description
MGF (Mechano Growth Factor) is the synthetic 24-amino acid E-domain peptide corresponding to the C-terminal extension of IGF-1Ec. It is the mechanically responsive splice variant of the IGF-1 gene expressed locally in skeletal muscle, cardiac tissue, and bone in response to mechanical loading or tissue damage. It was first characterized by Geoffrey Goldspink and colleagues at University College London, who demonstrated that mechanical stretch of muscle tissue induced rapid, transient IGF-1Ec expression that preceded and was distinct from the sustained liver-type IGF-1Ea response.
Chemical Information
- Chemical Name: MGF (Mechano Growth Factor; synthetic IGF-1Ec C-terminal peptide)
- Also Known As: Mechano Growth Factor; IGF-1Ec; IGF-1 splice variant
- Compound Class: Synthetic peptide fragment derived from the IGF-1Ec mRNA splice variant; local growth factor signaling peptide
- Sequence: Not established as a single standardized commercial sequence
- Molecular Formula: Not established in public literature for the synthesized research fragment
- Molecular Weight: Not established in public literature for the synthesized research fragment
- CAS Number: Not established in public literature
Applications
- Satellite cell activation and muscle regeneration research. MGF corresponds to a splice variant of the IGF-1 gene (IGF-1Ec in humans) upregulated locally in skeletal muscle tissue in response to mechanical loading or damage. This is in contrast to liver-derived systemic IGF-1. Its unique C-terminal E-domain is proposed to act locally within damaged muscle tissue to activate satellite (muscle stem) cells, driving their proliferation ahead of later IGF-1Ea-mediated differentiation
- Comparative IGF-1 splice variant research. MGF (IGF-1Ec) and mature IGF-1Ea arise from the same gene. However, they are proposed to act at different phases of the muscle repair process. MGF is for satellite cell activation/proliferation and IGF-1Ea for later differentiation. The two are studied together to map the temporal sequence of local muscle growth factor signaling
- Mechanotransduction research. MGF expression is directly linked to mechanical loading of muscle tissue, making it a research tool for studying how mechanical stimuli are converted into local growth factor gene expression changes in skeletal muscle
- Comparative research alongside PEG-MGF. MGF’s native form has a very short half-life in circulation. Therefore, researchers often pair it with PEG-MGF to compare local transient signaling versus prolonged systemic exposure effects in muscle research models
Storage and Handling
Store lyophilized powder at -20C for long-term stability, or at 2-8C for short-term use. Protect from heat, moisture, and direct light. MGF has a short half-life once in solution; reconstitute immediately before use, store reconstituted solution at 2-8C, use promptly, and avoid repeated freeze-thaw cycles.
Compliance Notice
MGF is for laboratory research use only. It is not for human or veterinary use and carries no therapeutic, diagnostic, or clinical indication. FDA has not evaluated this product. By purchasing this product, the buyer confirms that they will follow appropriate institutional safety procedures and use it exclusively for controlled research.
