Description
31 is a mitochondria-targeting tetrapeptide studied in controlled laboratory environments under the international nonproprietary name Elamipretide. Research interest in this compound centers on its interaction with cardiolipin — a phospholipid found almost exclusively in the inner mitochondrial membrane — and the role that interaction plays in membrane integrity, electron transport chain function, and mitochondrial bioenergetics research models.
Chemical Information
- Chemical Name: 31 (internal designation for Elamipretide)
- Also Known As: Elamipretide; SS-31; MTP-131; Bendavia
- Compound Class: Synthetic aromatic-cationic tetrapeptide; mitochondria-targeting cardiolipin-binding peptide
- Sequence: D-Arg-2′,6′-dimethyl-Tyr-Lys-Phe-NH2
- Molecular Formula: C32H49N9O5
- Molecular Weight: 639.8 g/mol
- CAS Number: 736992-21-5
Applications
- Cardiolipin binding and mitochondrial membrane integrity research. 31 selectively binds cardiolipin, a phospholipid found almost exclusively in the inner mitochondrial membrane. It is used to study how this interaction stabilizes respiratory chain supercomplexes and preserves membrane structure under stress conditions
- Electron transport chain and ATP synthesis research. Published work has examined 31’s effects on electron transport chain efficiency and ATP production in mitochondrial function assays. It positions it as a research tool for studying bioenergetic pathways independent of membrane potential-dependent targeting mechanisms
- Oxidative stress and reactive oxygen species (ROS) signaling research. 31 has been studied for its ability to reduce mitochondrial ROS output and lower cytochrome c peroxidase activity in stressed cell models. This supports its use in oxidative stress and redox signaling research
- Comparative mitochondria-targeted peptide research. As a member of the Szeto-Schiller peptide family, 31’s alternating aromatic-cationic sequence distinguishes its localization mechanism from cationic compounds that depend on membrane potential for mitochondrial accumulation. Researchers use this distinction when selecting mitochondria-targeting tools for membrane potential-independent study designs
- Aging and tissue energetics research models. Preclinical work has examined 31 in models of skeletal muscle dysfunction, cardiomyopathy, and age-related mitochondrial decline
Storage and Handling
Store lyophilized powder at -20C for long-term stability, or at 2-8C for short-term use. Protect from heat, moisture, and direct light. 31 is water-soluble and reconstitutes readily in aqueous buffer. As such, store reconstituted solution at 2-8C and use promptly, avoiding repeated freeze-thaw cycles.
Compliance Notice
31 is for laboratory research use only. It is not intended for human or veterinary use and carries no therapeutic, diagnostic, or clinical indication. This product has not been evaluated by the FDA. By purchasing this product, the buyer confirms it will be use it exclusively for controlled research following appropriate institutional safety procedures.
