Description
N-Acetyl Epithalon Amidate is a terminally modified analog of Epithalon and pineal neuroendocrine regulation. Together, these modifications protect both termini from the primary enzymatic attack routes, with dual-modified short peptides documented to achieve approximately 9.5-fold half-life improvement over unmodified sequences in biological matrices. Researchers studying specialty research peptide telomere biology and pineal signaling select this form when sustained compound exposure or direct comparison of modified vs unmodified AEDG behavior is the experimental goal.
Chemical Information
- Chemical Name: N-Acetyl Epithalon Amidate (N-acetylated, C-terminally amidated analog of Epithalon)
- Also Known As: Ac-Epithalon-NH2; acetylated Epithalon amide
- Compound Class: Modified synthetic tetrapeptide analog; stability-enhanced derivative of the Khavinson pineal bioregulator Epithalon (AEDG)
- Sequence: N-acetyl-Ala-Glu-Asp-Gly-amide (N-terminal acetylation and C-terminal amidation of the parent Epithalon sequence)
- Molecular Formula: Not established in public literature for the modified analog (parent Epithalon: C14H22N4O9)
- Molecular Weight: Not established in public literature for the modified analog (parent Epithalon: 390.3 g/mol)
- CAS Number: Not established in public literature for the modified analog (parent Epithalon: 307297-39-8)
Applications
- Peptide stability and pharmacokinetic modification research. N-terminal acetylation and C-terminal amidation reduce susceptibility to aminopeptidase and carboxypeptidase degradation. This analog is used in comparative research alongside unmodified Epithalon to study how these modifications affect proteolytic stability and functional persistence in cell-based assays
- Telomerase activity and cellular senescence research. Because the modified analog retains the core Ala-Glu-Asp-Gly sequence responsible for Epithalon’s reported telomerase-activating effects in cultured human cells, it is studied in the same experimental context as the parent compound to determine whether the terminal modifications preserve, enhance, or alter this activity
- Pineal and circadian signaling research. As a structural analog of the pineal bioregulator Epithalon, researchers use it in exploratory research on pineal gland function and melatonin-linked signaling pathways
- Note on evidence base: There is very little data specific to this compound. Most mechanistic and efficacy claims are extrapolated from research on unmodified Epithalon. Therefore, researchers should treat analog-specific claims as unverified pending direct study
Storage and Handling
Store lyophilized powder at -20C for long-term stability, or at 2-8C for short-term use. Protect from heat, moisture, and direct light. Store reconstituted solutions refrigerated at 2-8C and use promptly. Avoid repeated freeze-thaw cycles.
Compliance Notice
N-Acetyl Epithalon Amidate is for laboratory research use only. It is not for human or veterinary use and carries no therapeutic, diagnostic, or clinical indication. FDA has not evaluated this product. By purchasing this product, the buyer confirms that they will follow appropriate institutional safety procedures and use it exclusively for controlled research.
