Description
Epithalon is a synthetic tetrapeptide developed by Professor Vladimir Khavinson as the defined synthetic analog of epithalamin, a polypeptide extracted from bovine pineal gland tissue. It is the most extensively studied compound in the Khavinson bioregulator series, with over three decades of preclinical data across telomere biology, pineal neuroendocrine regulation, and cellular aging models. Its primary research interest centers on telomerase activation in somatic cells, specifically hTERT upregulation and telomere elongation in cell culture models.
Chemical Information
- Chemical Name: Epithalon (Ala-Glu-Asp-Gly, AEDG tetrapeptide)
- Also Known As: Epitalon; Epithalone; AEDG peptide
- Compound Class: Synthetic short-chain tetrapeptide; pineal gland-modeled bioregulator (Khavinson series)
- Sequence: Ala-Glu-Asp-Gly
- Molecular Formula: C14H22N4O9
- Molecular Weight: 390.3 g/mol
- CAS Number: 307297-39-8
Applications
- Telomerase activity and cellular senescence research. Epithalon is proposed to enter the cell nucleus and interact with chromatin to modulate genes linked to telomerase activity. Published in vitro work reported increased telomerase activity and telomere elongation in cultured human somatic cells following treatment, making it the most cited Khavinson-series peptide in cellular aging research
- Pineal gland and circadian/melatonin signaling research. As a synthetic analog of the pineal bioregulator complex Epithalamin, Epithalon is studied in models of pineal gland function, melatonin synthesis regulation, and circadian rhythm research, distinguishing its use case from tissue-restricted Khavinson peptides such as Cartalax or Cardiogen
- Monocyte/macrophage inflammatory signaling research. Published in vitro work using the human THP-1 monocytic line found that Epithalon, alongside Chonluten, Vilon, Thymogen, and Thymalin, suppressed LPS-stimulated TNF and IL-6 output. Researchers use this shared dataset to compare relative anti-inflammatory potency across the bioregulator family
- Comparative aging and geroprotector research. Epithalon carries the largest evidence base among Khavinson peptides for aging-related endpoints. As such, researchers use it frequently as the reference bioregulator in comparative geroprotector study designs alongside tissue-specific peptides such as Pinealon and Cortagen
- Note on evidence base: Most published data are preclinical (cell culture and animal models). Independent Western clinical trial data remain limited relative to the volume of Russian-language preclinical literature
Storage and Handling
Store lyophilized powder at -20C for long-term stability, or at 2-8C for short-term use. Protect from heat, moisture, and direct light. Keep reconstituted solutions refrigerated at 2-8C and use promptly. Avoid repeated freeze-thaw cycles, which can reduce peptide stability.
Compliance Notice
Epithalon is for laboratory research use only. It is not for human or veterinary use and carries no therapeutic, diagnostic, or clinical indication. This product has not been evaluated by the FDA. By purchasing this product, the buyer confirms that they will follow appropriate institutional safety procedures and use it exclusively for controlled research.
